The astonishing true story of how Catherine the Great joined forces with a Quaker doctor from Essex to spearhead one of the first global public health campaigns. A Times Best Book Of 2022 So Far Shortlisted for the Pushkin House Book Prize 2022 Sparkling history with a fairytale atmosphere of sleigh rides, royal palaces and heroic risk-taking The Times A killer virus an all-powerful Empress an encounter cloaked in secrecy the astonishing true story. Within living memory, smallpox was a dreaded disease. Over human history it has killed untold millions. Back in the eighteenth century, as epidemics swept Europe, the first rumours emerged of an effective treatment- a mysterious method called inoculation. But a key problem remained- convincing people to accept the preventative remedy, the forerunner of vaccination. Arguments raged over risks and benefits, and public resistance ran high. As smallpox ravaged her empire and threatened her court, Catherine the Great took the momentous decision to summon the Quaker physician Thomas Dimsdale to St Petersburg to carry out a secret mission that would transform both their lives. Lucy Ward expertly unveils the extraordinary story of Enlightenment ideals, female leadership and the fight to promote science over superstition. A rich and wonderfully urgent work of history Tristram Hunt.